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Using Zantac may increase your risk of developing pneumonia. Symptoms of pneumonia include chest pain, fever, feeling short of breath, and coughing up green or yellow mucus. Talk with your doctor about your specific risk of developing pneumonia.
Do not use Zantac if you are allergic to ranitidine.
Ask a doctor or pharmacist if it is safe for you to take this medicine if you have kidney disease, liver disease, or porphyria.
Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.
Zantac granules and effervescent tablets must be dissolved in water before you take them. Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor's directions about the type of antacid to use, and when to use it. Avoid drinking alcohol. It can increase the risk of damage to your stomach. It may take up to 8 weeks of using Zantac before your ulcer heals. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 6 weeks of treatment
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose

clexan:::

Clexane injection contains the active ingredient enoxaparin, which is a type of medicine called a low molecular weight heparin. It is used to stop blood clots forming within the blood vessels.
Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together and produce chemicals that activate the clotting process. The final part of this process involves a substance called thrombin being activated to produce a protein called fibrin. Fibrin binds the platelets together, forming a blood clot. This is the body’s natural way of repairing itself.
Sometimes, however, a blood clot can form abnormally within the blood vessels. This is known as a thrombus. It can be dangerous because the clot may detach and travel in the bloodstream, where it becomes known as an embolus. The embolus may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.
Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, in coronary artery disease, fatty deposits (atherosclerosis) on the walls of the coronary arteries can disrupt the blood flow, giving a tendency for platelets to clump together and start off the clotting process. When a clot has formed in a coronary artery this reduces the flow of blood to the heart and causes chest pain (angina). It can also result in a heart attack.
Slow blood flow in the leg and pelvic veins can also result in clots forming in these veins (deep vein thrombosis). These clots can break off and travel to the lungs (pulmonary embolism). Being immobile for long periods of time, for example due to a severe medical condition or following surgery, can increase the risk of these types of blood clot.
Enoxaparin is used to prevent and treat these types of abnormal blood clots. It works by inactivating thrombin in the clotting process described above. This stops the formation of fibrin, the essential component of blood clots. The medicine is administered by injection under the skin (subcutaneous injection).
Enoxaparin can also be used to prevent blood clotting when it is filtered through a kidney dialysis machine.

sandostatin

Sandostatin injection contains the active ingredient octreotide, which is a type of medicine called a somatostatin analogue. It is similar to a naturally occurring hormone in the body called somatostatin. Somatostatin is produced in various parts of the body, including the brain, gut and pancreas. It prevents the release of other hormones found in the body, such as growth hormone and insulin.
Octreotide is used to relieve the symptoms of gastroenteropancreatic (GEP) tumours. Most tumours of this type develop in the organs of the digestive system. They usually start in the cells of the stomach (gastro), intestines (entero) and the pancreas. These areas of the body produce various hormones, and tumours that grow in these areas often cause too much of a certain hormone to be produced. The type of hormone overproduced depends on the type of gland that is affected by the tumour.
The different types of GEP tumours are named after cells where they develop. Insulinomas occur in the pancreas, causing excessive amounts of insulin to be produced. This can cause a fall in blood sugar level (hypoglycaemia). Glucagonomas also occur in the pancreas, but these cause excessive amounts of glucagon to be produced. Glucagon increases blood sugar and tumours of this type can cause symptoms of diabetes.
Gastrinomas occur in the stomach, causing excessive amounts of gastrin to be produced. Gastrin causes the production of stomach acid. If too much gastric acid is produced this can lead to ulcers in the stomach, oesophagus and small intestine. VIPomas usually occur in the pancreas and produce too much of a substance called vasoactive intestinal peptide (VIP). This can cause watery diarrhoea.
Carcinoid tumours are usually found in the intestines. They can produce excessive amounts of the hormone serotonin. The serotonin causes various symptoms, including diarrhoea, that together are known as carcinoid syndrome.
Octreotide mimics the action of natural sandostatin and so decreases the production of these types of hormones. Octreotide only relieves the symptoms of these hormone-producing tumours, it does not cure the tumour.
Octreotide is also used to treat acromegaly, which is a condition characterised by enlarged facial features, hands and feet, that results from excessive production of growth hormone by a tumour in the pituitary gland. Octreotide decreases the production of the growth hormone and so treats the symptoms of the condition, however, again it does not cure the tumour.
For acromegaly, this medicine is used for short-term treatment prior to pituitary surgery. It can also be used for long-term treatment in those who are inadequately controlled by pituitary surgery or radiotherapy, in the interim period until radiotherapy becomes effective, or in people for whom surgery is inappropriate.
Sandostatin is a short-acting injection of octreotide that is usually given under the skin (subcutaneously) up to three times a day, depending on the condition being treated. Either you or a family member can be taught to give the injection.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

Side effects on the gut can be reduced by avoiding meals around the time of injection, ie timing the injections between meals or on going to bed. Ask your doctor or pharmacist for further advice.
The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to ensure that the combination is safe.
Octreotide can decrease the absorption of the immunosuppressant ciclosporin from the gut and so can make it less effective. The dose of ciclosporin may need to be increased.
People with diabetes who are treated with this medicine may need lower doses of insulin or antidiabetic tablets

paracetamol
How does it work?

Anadin paracetamol tablets contain the active ingredient paracetamol, which is a simple painkilling medicine used to relieve mild to moderate pain and fever. (NB. Paracetamol is also available without a brand name, ie as the generic medicine.)

Despite its widespread use for over 100 years, we still don't fully understand how paracetamol works to relieve pain and reduce fever. However, it is now thought that it works by reducing the production of prostaglandins in the brain and spinal cord.

Prostaglandins are produced by the body in response to injury and certain diseases. One of their actions is to sensitise nerve endings, so that when the injury is stimulated it causes pain (presumably to prevent us from causing further harm to the area). As paracetamol reduces the production of these nerve sensitising prostaglandins it is thought it may increase our pain threshold, so that although the injury remains, we can feel it less.

It is thought paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center).

Paracetamol is about as effective as aspirin at relieving mild to moderate pain and reducing fever, but unlike aspirin it has no anti-inflammatory effect.

Paracetamol can be used to relieve mild to moderate pain associated with conditions such as headaches, migraine, toothache, teething, colds and flu. It is also useful for reducing fever and discomfort associated with colds and flu and following vaccinations

Use in children:
Babies and children can take paracetamol from the age of three months.
Occasionally, your GP or doctor may advise that your child can take paracetamol when they are under three months' old.
For example, one dose of paracetamol may be given to children 2-3 months of age if they have a high temperature following vaccinations. This dose may be repeated once after 4-6 hours . But any further doses should be on the advice of your GP or doctor.
Up to two doses may also be given to babies 2-3 months of age for other causes of fever or mild pain, as long as the baby weighs over 4kg and was not born before 37 weeks of pregnancy. However, if the high temperature does not get better or your baby is still in pain, speak with your GP.


side effect

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

precautions

Acetaminophen passes into breast milk. Consult your doctor before breast-feeding

flagyl

This antibiotic only treats bacterial and protozoal infections. It will not work for viral infections (e.g., common cold, flu). Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.
How to use Flagyl Oral

Inform your doctor if your condition persists or worsens.

side effects

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اوك؟

insulin

How Does Insulin Work

Insulin activates the absorption of glucose from the blood by the cells of the muscle, liver and fat tissues. It also facilitates the storing of glucose as glycogen in the liver and muscle. Besides this, it prevents the use of fat for deriving energy.

Insulin is released in the body in two phases. The first phase involves the rapid release of a large amount of insulin in response to an increased level of glucose in the blood produced from the digestion of food. These high levels of insulin in the body induces the cells of the liver and muscles to absorb glucose from the blood. This results in a reduction in the blood glucose level. With the reduction of blood glucose level, insulin secretion also decreases. The second phase refers to the small amount of insulin continuously secreted by the beta cells, which is not dependent on the level of sugar. The body needs this small amount of insulin, as the liver keeps on releasing the stored sugar even when we are not eating. This ensures a constant supply of energy.

Insulin secreted in these ways enters the blood plasma and bind with beta globulin (a protein). Globulins are of two types, alpha and beta globulins, and are concerned with the circulation of lipids, vitamins and hormones throughout the body. When the blood plasma comes into contact with the liver and muscle cells, the insulin bounded to the beta globulins interact with the receptors (protein molecules) embedded in plasma membrane or cytoplasm of the cells. This in turn helps the passage of glucose into the cells.

In the absence of insulin, the absorption of glucose gets impaired due to which the body tends to use the stored fats to get energy. But, in the process the harmful byproducts, ketones are generated. On the other hand, since the body cannot absorb and utilize glucose in the absence of insulin, the blood glucose level increases.

Besides regulating the blood glucose level, insulin also affects many metabolic and other functions within the body. It is associated with the stimulation of some enzymes in the cells which induce many changes such as increase in glycogenesis or conversion of glucose into glycogen in the liver and muscles, and increase in the intake and utilization of glucose by the cells. In addition to all these, increased level of insulin stimulates the production of fat from glucose and prevents gluconeogenesis or generation of glucose from non-carbohydrate sources like lactate, glycerol, etc. It also plays an important role in the synthesis of DNA, RNA, cell replication and raises amino acid transportation to the cells.

Signs and Symptoms of Insulin Resistance

The first of the insulin resistance symptoms in men and women is fatigue. Since the body becomes insulin resistant, it wears out the person and the person is not able to work effectively. Fatigue can also be mental fatigue. People who are insulin resistant may suffer from poor memory, loss of creativity, poor grades, or even learning disabilities. These symptoms can more be glaring in case of students. The adults may not be able to notice these symptoms and often may tend to blame it on old age.

One of the insulin resistance symptoms is mild and brief periods of low blood sugar through the day. This situation may often arise, if the meals are not taken at the scheduled time. However, it is important to note, that extended period of low blood sugar, that is accompanied by physical and mental fatigue is not a normal sign. In such a case, you may want to talk to your health care professional regarding the same.

People who suffer from insulin resistance, may feel agitated, jittery and moody often. The next of the insulin resistance symptoms is often seen with a common man, but is more so with someone who suffers from insulin resistance. Immediately after eating a meal containing more than 20 to 30% carbohydrates, the person may feel extremely sleepy. You may also notice, that the person may doze off any time, sometimes also while sitting in their chair.

Obesity is one of the symptoms of insulin resistance. Too much of weight is a direct indicator of too much fat. In males the fat is accumulated around the abdomen and the large belly is often prominent. However, in case of women, the weight seen around the lower body especially in the thighs and buttocks. Hence, women who are insulin resistant often tend to have prominent buttocks.

Increased blood pressure can also be caused, due to insulin resistance. As a matter of fact, it has been observed, that most people who suffer from hypertension have too little insulin and are also insulin resistant. It is not difficult to prove the direct relation between the level of insulin and blood pressure, as when the insulin levels in the body increase, the blood pressure also increases.

Fatty liver is also one of the symptoms, that is associated with insulin resistance. There is accumulation of fat in the liver, due to manifestation of the disordered of lipids which occurs, when the person becomes insulin resistance.

Reproductive abnormalities in women are also observed as a result of insulin resistance. The woman may experience difficulty with ovulation and conception, irregular menses, etc. Some women may also suffer from Polycystic Ovarian Syndrome (PCOS). As opposed to this there are no known reproductive abnormalities observed in men, who are insulin resistant.

If you notice one or more of the insulin resistance symptoms, over a period of time, you may want to visit your health care professional. At the same time, make sure you have a balanced diet and regular exercise schedule, so that you do not have any complications

How to Measure Insulin Resistance
The symptoms of insulin resistance include fatigue, intestinal swelling, bloating, drowsiness, weight gain and depression. In case you are experiencing such symptoms and also have a family history of diabetes, then you must get a insulin resistance test done. A test known as hyperinsulinemic euglycemic clamp, is one way of ascertaining insulin resistance, but since it is a complicated method, it is generally used in medical research. Other blood tests that are used to measure insulin resistance are glucose tolerance test, fasting glucose test and fasting insulin test.

One of the most common test for ascertaining this condition is fasting blood glucose test. The normal blood sugar levels are 80 to 100 mg/dl, in case your blood sugar level is between 100-140 mg/dl, you might be insulin resistant. Another important test for diagnosing whether a person is suffering from insulin resistance or not, is glucose tolerance test.

This test requires overnight fasting. Blood will be drawn for a baseline blood glucose level. Then, the patient is given a sugar drink that contains about 75 grams of glucose. Then blood is drawn to check the blood glucose levels over the course of several hours. In case of people who are insulin resistant, the blood sugar levels stay abnormally high, as the insulin secreted by the pancreas is only partially absorbed by the tissues.

Wondering about insulin resistance test levels and how to measure them? Well, this will be measured by glucose tolerance test. You will have to drink a sweetened drink and reading will have to be taken after 2 hours. For the insulin resistance test, normal range should be below 140 mg/dl. In case, the test results indicate a reading of 140 to 199 mg/dl, it is indicative of pre-diabetes. Wondering whether you can perform the insulin resistance test at home? Though you might be able to check your blood glucose level at home, but that is not enough to measure insulin resistance.

The glucose tolerance test alone might not be sufficient for diagnosing insulin resistance, therefore, it must be analyzed along with insulin test results. Though the fasting insulin test is variable, but high insulin levels generally point towards an insulin resistance. Besides these tests, a lipid profile may also be ordered in order to measure LDL, HDL, triglycerides and total cholesterol. If the tests show increased levels of triglycerides and LDL and low HDL concentration, the probability of a person suffering from insulin resistance is high.

So, this was some information on insulin resistance test results. If you have been experiencing insulin resistance symptoms, you must consult a doctor soon. If detected at an early stage, you can make some changes in your diet and reduce your chances of developing diabetes

Before Injecting

The first step is locating the area where insulin is to be injected. There are many places in the body which can be injected. Certain parts can be more sensitive to insulin as compared to others. For instance, muscular areas are more sensitive to insulin than fatty areas. The tummy or hips may not be as sensitive as buttocks or thighs. One of the reasons why injections should be taken in the above mentioned areas is that, fats absorb insulin much better and faster than the other body parts. Fat parts also have less nerve endings, resulting in less pain.

It is recommended by doctors to avoid getting injected in areas which are frequently exercised. Once a part is injected, there should be a big time lapse before the same part is injected again. But at the same time, care should be taken to maintain the area of injection after a routine or one complete cycle. For example, if you decide to inject your arm once, the next time it would be a different part, like the abdomen. But the same hand can be injected again the next day and so on. Using the same parts of the body will ensure predictability of the effect and define the insulin level in the body. This would make tracking the results or improvements, a lot easier.

Lot of people are wary of injections and opt for alternative treatments like oral medication. But, people with type 1 diabetes have to compulsorily take an insulin injection. The technology for administering an insulin dose via needle, has significantly improved. Although, it is not pain free, the intensity of pain is definitely far less than what used to be in the olden days. Another concern is, whether it is possible or correct to take an injection with clothes on or through a cloth. The answer would be an overwhelming 'no'. There are two simple reasons for that - first, a cloth is not sterile. The needle may get contaminated and cause infection in the body part. Another point, is that a needle tip is lubricated to make the procedure less painful. After passing through a cloth, some of the lubricant may come off, eventually causing a bit more pain.

Steps for Injecting Insulin

These are the steps to be followed for taking an insulin injection. It is always recommended to take the advise of your doctor or a diabetes specialist before injecting yourself with insulin.

A careful and systematic approach is absolutely essential for conducting the above procedure. Two or three injecting sessions are sufficient to confidently administer the insulin, in a proper way. Have a safe, balanced and healthy lifestyle to keep diabetes at bay.

Causes for Side Effects of Insulin

Side Effects of Insulin

There are six types of insulin classified based on the duration of action on the human body. The types of insulin available are rapid-acting, short-acting, intermediate-acting, long-acting, very long-acting and premix. Short-acting insulin is given in the abdomen, long-acting insulin is given in the thighs and insulin premix is given in the abdomen or thighs. Side effects of insulin are a rare sight. Dosage of insulin varies according to the patient. Insulin is given to the patient using syringes, pens and pumps. Some of the side-effects are as follows:

Hypoglycemia: The glucose levels in the human brain drops down. The symptoms of hypoglycemia are sweating, dizziness, excessive hunger, increase in pulse rate, and blurred vision. Eating small amounts of food that is rich in sugar gives temporary relief from hypoglycemia. Hypoglycemia directly affects the brain tissues. Severe hypoglycemia may result in coma. The sugar levels should be checked immediately after hypoglycemia. Checking sugar levels helps in further treatment of diabetes.

Weight gain: In diabetes, calories are not well-utilized. Intake of insulin increases the use of calories consumed by human body, this leads to weight gain. Weight gain in diabetes can be a serious issue. Diabetic patients must be very careful about the changes in their weight.

Loss of fatty tissues: Taking frequent injections of insulin can damage the fatty tissues in the injected area. Improper hygiene during medication may cause infections.

Allergic reactions: The area where the insulin is injected turns red and becomes itchy. Edema (swelling) is observed on a part or the whole body in some cases, due to excessive water retention. These side-effects are usually seen in first few weeks of therapy. In case allergic reactions last for more than two weeks, you should consult your physician. Syringes and pens used to take insulin should never be shared with others to avoid infections.

Upper respiratory tract problems: Coughing, respiratory tract infections and difficulty in breathing is seen in patients taking insulin via a pump. Very few patients are recommended to take insulin using an insulin pump.

Interactions with other drugs: The effect of insulin is nullified by many drugs consumed. These drugs may cause hyperglycemia in diabetic patients. Oral diabetic medications, alcoholic beverages, sulfonamide antibiotics, aspirin, Fibrate cholesterol medications, growth hormones are some of the drugs with which insulin reacts. Patients should consult the doctor if they are on some other drugs before taking insulin.

Pregnant women should take insulin only under medical observation. Breast-feeding mothers must adjust their insulin dosage with their diabetic diet. Insulin is prescribed by the physician taking into consideration many other aspects. Some of these aspects are your age, lifestyle, individual body response to insulin and blood sugar levels. Insulin must be taken under proper medical observation.

Heparin sodium injection is a type of medicine called an anticoagulant. It is used to stop blood clots forming within the blood vessels. Heparin sodium is sometimes referred to as standard or unfractionated heparin.
Blood clots normally only form to stop bleeding that has occurred as a result of injury to the tissues. The clotting process is complicated and begins when blood cells called platelets clump together and produce chemicals that activate the clotting process. The final part of this process involves a substance called thrombin being activated to produce a protein called fibrin. Fibrin binds the platelets together, forming a blood clot. This is the body’s natural way of repairing itself.
Heparin works by inactivating thrombin in the clotting process. This stops the formation of fibrin and so stops blood clots forming. Heparin is used to treat blood clots that have formed abnormally inside the blood vessels. It can also be used to prevent these types of dangerous blood clots.
A blood clot that forms abnormally within the blood vessels is known as a thrombus. It can be dangerous because the clot may detach and travel in the bloodstream (where it becomes known as an embolus) and may eventually get lodged in a blood vessel, thereby blocking the blood supply to a vital organ such as the heart, brain or lungs. This is known as a thromboembolism.
Some people have an increased tendency for blood clots to form within the blood vessels. This is usually due to a disturbance in the blood flow within the blood vessels. For example, in coronary artery disease, fatty deposits (atherosclerosis) on the walls of the coronary arteries can disrupt the blood flow, giving a tendency for platelets to clump together and start off the clotting process. Unstable coronary artery disease means that a furred up bit of the artery has ruptured and a clot has formed on it, reducing the flow of blood to the heart. This causes chest pain (angina) and can result in a heart attack.
Slow blood flow in the leg and pelvic veins can also result in clots forming in these blood vessels (deep vein thrombosis). These clots can break off and travel to the lungs (pulmonary embolism). Being immobile for long periods of time, for example due to a severe medical condition or following surgery, can increase the risk of these types of blood clot, as can pregnancy, obesity and certain blood disorders.
Heparin is given by injection or drip into a vein (intravenously) or by injection under the skin (subcutaneously) to treat and prevent these types of blood clots. The dose and length of treatment used will depend on the nature of the clot being treated or prevented.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to ensure that the combination is safe.
There may be an increased anti-blood-clotting effect, which can result in an increased risk of bleeding or increased time taken to stop bleeding, if any of the following medicines are used in combination with heparin:

If you are given any of these your doctor or pharmacist will adjust the doses of your medicines so that the appropriate effect on your blood clotting time is achieved.
There may an increased risk of a rise in the amount of potassium in your blood if heparin is used in combination with the following medicines, which can also raise blood potassium:

The amount of potassium in your blood should be regularly monitored if you are taking any of these while being treated with heparin.
The anticoagulant effect of heparin may be reduced by drips (intravenous infusions) of nitrate medicines such as glyceryl trinitrate.

Burinex tablets contain the active ingredient bumetanide, which is a type of medicine called a loop diuretic. (NB. bumetanide is also available without a brand name, ie as the generic medicine.)
Diuretics are sometimes referred to as 'water tablets'. They remove excess fluid from the body by increasing the production of urine.
Loop diuretics work by causing the kidneys to increase the amount of salts such as potassium and sodium that are filtered out of the blood and into the urine. When these salts are filtered out of the blood by the kidneys, water is also drawn alongside. As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood and into the urine.
Bumetanide is used to treat conditions where excess fluid has been retained in the body (oedema). For example, in heart failure, the pumping mechanism of the heart is less effective. This can cause fluid to build up in the ankles and the lungs (pulmonary oedema), which makes it difficult to breathe. Bumetanide helps the body to remove this excess fluid. Removing fluid from the blood vessels also decreases the pressure within the blood vessels. This makes it easier for a weak heart to pump blood around the body. Bumetanide is therefore used to relieve the symptoms of heart failure.
Bumetanide is also used to remove excess fluid that can accumulate in people with cirrhosis of the liver. This fluid may accumulate in the abdomen or in the legs (peripheral oedema).
Problems with blood circulation in the legs can also cause fluid retention and swelling of the ankles or lower legs, and this can also be treated with bumetanide.
At higher doses the amount of water drawn from the blood into the urine is much greater, therefore bumetanide is also used when there is reduced production of urine in people with kidney failure.
As bumetanide decreases the pressure within the blood vessels, it is also sometimes used to treat high blood pressure, usually in people resistant to other blood pressure lowering medicines.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while having treatment with this one, to ensure that the combination is safe.
Bumetanide decreases blood pressure. If it is used in combination with other medicines that lower blood pressure, either as a side effect, or to treat high blood pressure (antihypertensives), the combination might lower your blood pressure too much and make you feel dizzy or faint. Your doctor may need to adjust your doses. Other medicines that decrease blood pressure include the following:

If you are due to start treatment with an ACE inhibitor, angiotensin-II receptor antagonist, or alpha-blocker, your doctor may stop your treatment with bumetanide or reduce your dose for a few days beforehand, in order to avoid your blood pressure falling too low with the first dose of the new medicine.
There may be an increased risk of side effects on the kidneys if this medicine is used in combination with the following medicines:

There may be an increased risk of side effects on the ears if this medicine is used in combination with the following medicines:

The following medicines may decrease the blood pressure lowering and diuretic effects of bumetanide:

Bumetanide may increase the blood level of the medicine lithium. People taking lithium together with furosemide should have the level of lithium in their blood closely monitored.
Bumetanide can increase blood glucose levels and people with diabetes may therefore need increases in their dose of insulin or antidiabetic tablets. Blood sugar levels should be monitored.
Bumetanide can decrease the amount of potassium in the blood. If it is used in combination with any of the following medicines, which can also lower potassium in the blood, the risk of a low blood potassium level (hypokalaemia) is increased:

If the level of potassium in your blood falls during treatment, this can increase the risk of side effects on the heart caused by the following medicines:

Bumetanide tablets are also available without a brand name, ie as the generic medicine.

unasyn

How to use Unasyn IV

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or to penicillin or cephalosporin antibiotics; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: viral infections (e.g., infectious mononucleosis), kidney disease.
This medication contains sodium. Consult your doctor or pharmacist if you are on a salt-restricted diet or if you have a condition that could be worsened by an increase in salt intake (e.g., congestive heart failure).
Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
This medication passes into breast milk. Consult your doctor before breast-feeding

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